Detalhe da pesquisa
1.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Cell
; 185(4): 712-728.e14, 2022 02 17.
Artigo
Inglês
| MEDLINE | ID: mdl-35063084
2.
Reducing acetylated tau is neuroprotective in brain injury.
Cell
; 184(10): 2715-2732.e23, 2021 05 13.
Artigo
Inglês
| MEDLINE | ID: mdl-33852912
3.
Amyloid beta emerges from below the neck to disable the brain.
PLoS Biol
; 19(9): e3001388, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34525093
4.
Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.
Bioessays
; 39(4)2017 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28083916
5.
Acute knockdown of AMPA receptors reveals a trans-synaptic signal for presynaptic maturation.
EMBO J
; 30(8): 1577-92, 2011 Apr 20.
Artigo
Inglês
| MEDLINE | ID: mdl-21378752
6.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
J Clin Invest
; 134(3)2024 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38299587
7.
Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction.
Res Sq
; 2023 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37986935
8.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
bioRxiv
; 2023 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37398236
9.
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Nat Neurosci
; 26(5): 737-750, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37095396
10.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Sci Transl Med
; 13(622): eabe3947, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34851693
11.
Astrocyte senescence promotes glutamate toxicity in cortical neurons.
PLoS One
; 15(1): e0227887, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-31945125
12.
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Neuron
; 104(3): 458-470.e5, 2019 11 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31542321
13.
Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.
Curr Opin Neurobiol
; 51: 134-138, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29753269
14.
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.
Neuron
; 98(1): 75-89.e5, 2018 04 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29551491
15.
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.
Stem Cell Reports
; 9(4): 1221-1233, 2017 10 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28966121
16.
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Mol Neurodegener
; 11(1): 47, 2016 06 29.
Artigo
Inglês
| MEDLINE | ID: mdl-27356871
17.
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
Neuron
; 90(2): 245-60, 2016 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-27041503
18.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Nat Med
; 21(10): 1154-62, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26390242